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Age-related decline in NAD+ can cause low energy and poor cognition

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Both act on lipid metabolism rather than central hunger circuits, making them relevant to research focused on adiposity endpoints independent of caloric intake

Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study